The experience of depression can often involve a long and challenging journey. Many individuals grapple with the condition, seeking help and trying various treatments, only to find that relief remains elusive. This persistent struggle, known as treatment-resistant depression (TRD), can be incredibly isolating. However, advancements in therapeutic options may offer new paths forward.

 

Esketamine is a prescription nasal spray medication specifically designed for adults with treatment-resistant depression. Unlike traditional antidepressants that primarily target serotonin, norepinephrine, or dopamine, esketamine works on a different pathway in the brain, offering a unique approach to help alleviate severe depressive symptoms when other therapies have not been successful. “Esketamine targets a novel pathway that results in rapid changes in depressive symptoms,” says George Lasker, MD, Inpatient Psychiatrist at Mather Hospital. “It is one of the fastest and most efficacious treatments we currently have in the field of psychiatry.” This treatment is administered in a supervised clinical setting to ensure your safety and well-being.

Esketamine treatment is not for everyone, but it could be a significant step forward if you meet certain criteria. You may be a candidate for esketamine therapy if:

  • -You have been diagnosed with depression that has not improved adequately after trying at least two other antidepressant treatments.
  • -You are currently under the active care of a psychiatrist who will continue to manage your overall mental health.
  • -Your psychiatrist believes esketamine may be beneficial and refers you to our specialized program.

 

If esketamine treatment is determined to be a suitable option, here is a general overview of what your treatment journey will look like:

  • -Induction phase: For the first four weeks, treatments are typically administered twice per week. This intensive period aims to help establish a response to the medication. Treatment is not always administered at the initial appointment. A comprehensive evaluation with a psychiatrist is needed to determine eligibility for the treatment.
  • -Optimization/maintenance phase: Following the initial phase, the frequency of treatments will be adjusted to your individual needs, typically ranging from weekly to bi-weekly sessions.
  • -Visit duration: Each treatment session lasts approximately two and a half hours. This allows ample time for the medication to be administered and for our experienced medical team to monitor you closely.
  • -Close monitoring: Throughout each session, you will be carefully observed for any side effects or changes in your condition, ensuring your comfort and safety.
  • -Transportation: For your safety, it is crucial that you arrange transportation home after every visit. You will not be able to drive yourself.

 

If you or someone you care about is struggling with treatment-resistant depression and seeking a new ray of hope, do not hesitate to learn more about esketamine therapy. You do not have to face this alone. Contact Mather Hospital’s Behavioral Health Services today to explore if esketamine treatment could be the path to the relief you deserve. Our compassionate team at Mather Hospital is here to answer your questions and help you take the next step on your journey toward better mental well-being.

 

George Lasker, MD, Inpatient Psychiatrist at Mather Hospital